Other than full-on track rats, most won't notice the difference in compressibility between DOT5 and DOT3/4/5.1 fluids, but it can be quite noticeable in performance applications, particularly ones that run higher brake pressures.
The fact that water and silicone do not mix means that water is much less likely to get into a system filled with DOT5, but when it does get in, it just puddles up at the low points and sits there waiting to be turned to steam and corroding whatever metal it lays in contact with, and no amount of bleeding will typically remove the water from the system without completely disassembling the calipers.
DOT3/4/5.1 glycol fluids will mix with whatever water enters the system and flush out with the brake fluid with you bleed the brakes. When you look at the "wet boiling point" of brake fluid, it is measured at 3.7% water by volume, which is an estimate for how much water can accumulate in the brake fluid over a 2-year service interval. DOT3 fluid with 8% water by volume has almost the same boiling point as water, so fresh brake fluid is a good thing and flushing your system with new fluid every 2 years or so is probably the best way to extend the life of the system while maximizing performance.